How Does Proliferative Homeostasis Change With Age? What Causes It and How Does It Contribute to Aging?

Abstract excerpt

The notion that there might be a cellular basis for aging stems from research that began several decades ago and was proposed to explain the loss of proliferative homeostasis, which is a hallmark of complex animals. Recent years have seen growing support for the idea that two cell fates-apoptosis and cellular senescence, both now well-established tumor suppressor mechanisms-may be important drivers of aging...

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