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Is senescence-associated β-galactosidase a marker of neuronal senescence?

Oncotarget - 6 Dec 2016

Piechota Malgorzata, Sunderland Piotr, Wysocka Adrianna, Nalberczak Maria, Sliwinska Malgorzata A, Radwanska Kasia, Sikora Ewa

Abstract excerpt

One of the features of cellular senescence is the activity of senescence-associated- β-galactosidase (SA-β-gal). The main purpose of this study was to evaluate this marker of senescence in aging neurons. We found that cortical neurons exhibited noticeable SA-β-gal activity quite early in culture. Many SA-β-gal-positive neurons were negative for another canonical marker of senescence, namely, double-strand DNA...

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PMID: 27768595
DOI: 10.18632/oncotarget.12752
PMCID: PMC5348379

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