β‐Galactosidase Activity as a Biomarker of Replicative Senescence during the Course of Human Fibroblast Cultures

Abstract excerpt

It has been called into question whether the commonly used beta-galactosidase staining is a reliable biomarker of cellular senescence because induction of beta-galactosidase activity also occurs independently of senescence. Here, we tested whether cytochemically detectable beta-galactosidase activity is reproducible and reflects the rate of cellular aging in vitro. Therefore, we serially cultured fibroblasts from...

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