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Article

Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization.

Journal of cell science - 1 Jul 2005

Akhavan Armin, Atanasiu Roxana, Noguchi Tomohiro, Han Wei, Holder Natasha, Shrier Alvin

Abstract excerpt

Mutations of a putative cyclic-nucleotide-binding domain (CNBD) can disrupt the function of the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN2) and the human ether-a-go-go-related gene potassium channel (HERG). Loss of function caused by C-terminal truncation, which includes all or part of the CNBD in HCN and HERG, has been related to abnormal channel trafficking. Similar defects have been...

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Source

Identifiers

PMID: 15961404
DOI: 10.1242/jcs.02423

Genes

HCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization.PMID 15961404Read ↗

Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2.Semantic proximity Read ↗

Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing.Semantic proximity Read ↗

Identification of a COOH-terminal segment involved in maturation and stability of human ether-a-go-go-related gene potassium channels.Semantic proximity Read ↗

Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene.Semantic proximity Read ↗

Trafficking-deficient hERG K⁺ channels linked to long QT syndrome are regulated by a microtubule-dependent quality control compartment in the ER.Semantic proximity Read ↗

Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons.Semantic proximity Read ↗

Structure of the C-terminal region of an ERG channel and functional implications.Semantic proximity Read ↗

Defective human Ether-à-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus.Semantic proximity Read ↗

Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome.Semantic proximity Read ↗

Functional evaluation of Dent’s disease-causing mutations: implications for ClC-5 channel trafficking and internalizationSemantic proximity Read ↗

Effects of N-glycosylation on hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.Semantic proximity Read ↗

Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal.Semantic proximity Read ↗

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