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Article

Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2.

The Journal of biological chemistry - 18 May 2001

Cui J, Kagan A, Qin D, Mathew J, Melman Y F, McDonald T V

Abstract excerpt

Mutations in the cyclic nucleotide binding domain (CNBD) of the human ether-a-go-go-related gene (HERG) K+ channel are associated with LQT2, a form of hereditary Long QT syndrome (LQTS). Elevation of cAMP can modulate HERG K+ channels both by direct binding and indirect regulation through protein kinase A. To assess the physiological significance of cAMP binding to HERG, we introduced mutations to disrupt the...

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Identifiers

PMID: 11278781
DOI: 10.1074/jbc.M010904200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2.PMID 11278781Read ↗

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