Article
Axenfeld-Rieger syndrome-associated mutants of the transcription factor FOXC1 abnormally regulate NKX2-5 in model zebrafish embryos.
The Journal of biological chemistry - 14 Aug 2020
Zhang Qinxin, Liang Dong, Yue Yunyun, He Luqingqing, Li Nan, Jiang Dongya, Hu Ping, Zhao Qingshun
Abstract excerpt
FOXC1 is a member of the forkhead family of transcription factors, and whose function is poorly understood. A variety of FOXC1 mutants have been identified in patients diagnosed with the autosomal dominant disease Axenfeld-Rieger syndrome, which is mainly characterized by abnormal development of the eyes, particularly those who also have accompanying congenital heart defects (CHD). However, the role of FOXC1 in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.