Article
Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic Shuttling
31 Aug 2015
Abstract excerpt
A dynamic distribution between nucleus and cytoplasm (nucleocytoplasmic shuttling) is one of the control mechanisms adapted by normal cells to regulate the activity of a variety of molecules. Growing evidence suggests that dysregulation of the nucleocytoplasmic shuttling is involved in promoting abnormal cell survival, tumor progression, and drug resistance, and is associated with poor cancer prognosis. Aberrant...
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