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SINE (selective inhibitor of nuclear export) – translational science in a new class of anti-cancer agents

3 Oct 2014

Abstract excerpt

Regulation of protein trafficking between the nucleus and cytoplasm represents a novel control point for antineoplastic intervention. Several proteins involved with cellular growth and survival depend on precise and timely positioning within the cell to fulfill their functions, and the nuclear membrane defines one of the most important compartmental barriers. Chromosome Region Maintenance 1, or exportin-1...

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PMID: 25281264
DOI: 10.1186/s13045-014-0067-3

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