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Article

GBA variation and susceptibility to multiple system atrophy.

Parkinsonism & related disorders - 1 Aug 2020

Wernick Anna I, Walton Ronald L, Koga Shunsuke, Soto-Beasley Alexandra I, Heckman Michael G, Gan-Or Ziv, Ren Yingxue, Rademakers Rosa, Uitti Ryan J, Wszolek Zbigniew K, Cheshire William P, Dickson Dennis W, Ross Owen A

Abstract excerpt

INTRODUCTION: Genetic variants in the glucocerebrosidase (GBA) gene have been previously associated with susceptibility to synucleinopathies. The risk is well-established in Lewy body disease but is not as confirmed for multiple system atrophy (MSA). We aim to evaluate associations between exonic variants in GBA and risk of neuropathologically-confirmed multiple system atrophy (MSA). METHODS: Sanger gene...

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PMID: 32623306
DOI: 10.1016/j.parkreldis.2020.06.007

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