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Article

Frequency of <i>GBA</i> Variants in Autopsy‐proven Multiple System Atrophy

11 Feb 2017

Abstract excerpt

Abstract Background Multiple system atrophy ( MSA ) is marked by abnormal inclusions of α‐synuclein in oligodendrogliocytes, and its etiology remains unknown. Variants in the glucocerebrosidase ( GBA ) gene have been associated with the other synucleinopathies, dementia with Lewy bodies, and Parkinson's disease. It is unclear whether glucocerebrosidase variants are associated with MSA . The objective of this...

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PMID: 28966932
DOI: 10.1002/mdc3.12481

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