Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2014

Pilla Danielle M, Hagar Jon A, Haldar Arun K, Mason Ashley K, Degrandi Daniel, Pfeffer Klaus, Ernst Robert K, Yamamoto Masahiro, Miao Edward A, Coers Jörn

Abstract excerpt

IFN receptor signaling induces cell-autonomous immunity to infections with intracellular bacterial pathogens. Here, we demonstrate that IFN-inducible guanylate binding protein (Gbp) proteins stimulate caspase-11-dependent, cell-autonomous immunity in response to cytoplasmic LPS. Caspase-11-dependent pyroptosis is triggered in IFN-activated macrophages infected with the Gram-negative bacterial pathogen Legionella...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspases
Share to Legionella pneumophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Legionnaires' Disease

Share to Macrophage Activation

Share to NADPH Oxidase 2

Share to NADPH Oxidases

Share to Nitric Oxide Synthase Type II

Share to Salmonella typhimurium

Source

Open in PubMed Open full text

Identifiers

PMID: 24715728
DOI: 10.1073/pnas.1321700111
PMCID: PMC4000848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.PMID 24715728Read ↗

GBP2 aggregates LPS and activates the caspase-4 inflammasome independent of the bacterial encapsulation factor GBP1Semantic proximity Read ↗

Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosaSemantic proximity Read ↗

Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐NLRP3 inflammasomesSemantic proximity Read ↗

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusionSemantic proximity Read ↗

Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infectionSemantic proximity Read ↗

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in MammalsSemantic proximity Read ↗

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.Semantic proximity Read ↗

The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondiiSemantic proximity Read ↗

Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathwaysSemantic proximity Read ↗

Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9Semantic proximity Read ↗

GBP1 recruitment to actin-rich pedestals induced by extracellular Gram-negative bacteria promotes pyroptosisSemantic proximity Read ↗

IRG1 and iNOS act redundantly with other interferon gamma-induced factors to restrict intracellular replication of <i>Legionella pneumophila</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.