Article
Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder.
Molecular psychiatry - 1 Sept 2021
Fears Scott C, Service Susan K, Kremeyer Barbara, Araya Carmen, Araya Xinia, Bejarano Julio, Ramirez Margarita, Castrillón Gabriel, Gomez-Franco Juliana, Lopez Maria C, Montoya Gabriel, Montoya Patricia, Aldana Ileana, Teshiba Terri M, Al-Sharif Noor B, Jalbrzikowski Maria, Tishler Todd A, Escobar Javier, Ruiz-Linares Andrés, Lopez-Jaramillo Carlos, Macaya Gabriel, Molina Julio, Reus Victor I, Cantor Rita M, Sabatti Chiara, Freimer Nelson B, Bearden Carrie E
Abstract excerpt
Bipolar disorder is a highly heritable illness, associated with alterations of brain structure. As such, identification of genes influencing inter-individual differences in brain morphology may help elucidate the underlying pathophysiology of bipolar disorder (BP). To identify quantitative trait loci (QTL) that contribute to phenotypic variance of brain structure, structural neuroimages were acquired from family...
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