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Article

Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds.

mBio - 30 Jun 2020

Wurster Sebastian, Tatara Alexander M, Albert Nathaniel D, Ibrahim Ashraf S, Heitman Joseph, Lee Soo Chan, Shetty Amol C, McCracken Carrie, Graf Karen T, Mikos Antonios G, Bruno Vincent M, Kontoyiannis Dimitrios P

Abstract excerpt

Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of NMM have been associated with extreme mechanical forces (e.g., during tornados), we studied the impact of mechanical stress on Mucoralean biology and virulence in a Drosophila...

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Identifiers

PMID: 32605990
DOI: 10.1128/mBio.01414-20
PMCID: PMC7327176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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