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Host Lung Environment Limits Aspergillus fumigatus Germination through an SskA-Dependent Signaling Response

8 Dec 2021

Abstract excerpt

Aspergillus fumigatus is an important human fungal pathogen particularly in immunocompromised individuals. Initiation of growth by A. fumigatus in the lung is important for its pathogenicity in murine models. However, our understanding of what regulates fungal germination in the lung environment is lacking. Through a serial passage experiment using lung-based medium, we identified a new strain of A. fumigatus...

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PMID: 34878292
DOI: 10.1128/msphere.00922-21

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