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Article

Individual susceptibility has a major impact on strong association between oxidative stress, defence systems and Parkinson's disease.

Basic & clinical pharmacology & toxicology - 1 Jan 2022

Karahalil Bensu, Miser Salihoğlu Ece, Elkama Aylin, Orhan Gürdal, Saygın Evrim, Yardim Akaydin Sevgi

Abstract excerpt

Oxidative stress plays an important role in the degeneration of dopaminergic neurons, which causes Parkinson's disease (PD). Oxidative stress products, antioxidant and their balance have important roles in the development of oxidative stress-based PD. The impact of reactive oxygen species (ROS) and defence systems can be altered by genetic polymorphisms, and thus the risk of PD may also be affected. We aimed to...

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PMID: 34582115
DOI: 10.1111/bcpt.13659

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