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Article

6-s-cis Conformation and polar binding pocket of the retinal chromophore in the photoactivated state of rhodopsin.

Journal of the American Chemical Society - 28 Oct 2009

Ahuja Shivani, Eilers Markus, Hirshfeld Amiram, Yan Elsa C Y, Ziliox Martine, Sakmar Thomas P, Sheves Mordechai, Smith Steven O

Abstract excerpt

The visual pigment rhodopsin is unique among the G protein-coupled receptors in having an 11-cis retinal chromophore covalently bound to the protein through a protonated Schiff base linkage. The chromophore locks the visual receptor in an inactive conformation through specific steric and electrostatic interactions. This efficient inverse agonist is rapidly converted to an agonist, the unprotonated Schiff base of...

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Identifiers

PMID: 19795853
DOI: 10.1021/ja9034768
PMCID: PMC2783296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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