Spectroscopic evidence for altered chromophore--protein interactions in low-temperature photoproducts of the visual pigment responsible for congenital night blindness.

doi:10.1021/bi961486s

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Article

Spectroscopic evidence for altered chromophore--protein interactions in low-temperature photoproducts of the visual pigment responsible for congenital night blindness.

Biochemistry - 26 Nov 1996

Fahmy K, Zvyaga T A, Sakmar T P, Siebert F

Abstract excerpt

The replacement of Gly90 by Asp in human rhodopsin causes congenital night blindness. It has been suggested that the molecular origin for the trait is an altered electrostatic environment of the protonated retinal Schiff base chromophore. We have investigated the corresponding recombinant bovine...

Topics

Amides
Animals
Cattle
Electrochemistry
Mutation
Night Blindness
Photochemistry
Recombinant Proteins
Rhodopsin
Schiff Bases
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Temperature

Source

Open in PubMed

Identifiers

PMID: 8942673
DOI: 10.1021/bi961486s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8942673-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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