Article

How Does Maternal Immune Activity Affect Fetal Survival and Brain Development?: The Critical Roles of IL-17A and Microglia

2025-08-25

Abstract excerpt

Maternal immune activation (MIA) during pregnancy has been associated with increased risk of fetal loss and neurodevelopmental disorders in offspring. This review summarizes recent findings on the effects of MIA on fetal survival and microglial phenotype. Studies using polyinosinic-polycytidylic acid (poly(I: C))-induced MIA mouse models have revealed a crucial role for interleukin-17A (IL-17A) in mediating these...

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Literature Corpus work: c77bde73-fdbe-56ef-a217-20baab71ee27
DOI: 10.20944/preprints202508.1734.v1

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