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Article

From Mouse Models to Human Disease: An Approach for Amyotrophic Lateral Sclerosis.

In vivo (Athens, Greece) - 1 Jan 2000

Alrafiah Aziza Rashed

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder. There are several genetic mutations that lead to ALS development, such as chromosome 9 hexanucleotide repeat 72 (C9ORF72), transactive response DNA-binding protein (TARDBP), superoxide dismutase 1 (SOD1) and fused in sarcoma (FUS). ALS is associated with disrupted gene homeostasis causing aberrant RNA processing or toxic...

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Source

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Identifiers

PMID: 30150420
DOI: 10.21873/invivo.11339
PMCID: PMC6199613

Genes

TARDBP
FUS
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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