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Article

An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila.

Molecular cell - 16 Jul 2020

Weigelt Carina Marianne, Sehgal Rohan, Tain Luke Stephen, Cheng Jun, Eßer Jacqueline, Pahl André, Dieterich Christoph, Grönke Sebastian, Partridge Linda

Abstract excerpt

Circular RNAs (circRNAs) are abundant and accumulate with age in neurons of diverse species. However, only few circRNAs have been functionally characterized, and their role during aging has not been addressed. Here, we use transcriptome profiling during aging and find that accumulation of circRNAs is slowed down in long-lived insulin mutant flies. Next, we characterize the in vivo function of a circRNA generated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32592682
DOI: 10.1016/j.molcel.2020.06.011
PMCID: PMC7318944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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