Article
The RNA-binding protein NOVA-1 regulates circRNA expression, alternative splicing, and aging in Caenorhabditis elegans.
G3 (Bethesda, Md.) - 1 Apr 2026
Adeyemi Emmanuel, Alshareef Hussam Z, Bhat Jaffar M, Miura Pedro, van der Linden Alexander M
Abstract excerpt
Circular RNA (circRNA) biogenesis is regulated by RNA-binding proteins (RBPs) that alter back-splicing of exons in protein-coding genes. However, few in vivo roles for RBPs in the regulation of circRNA biogenesis have been characterized. We previously showed that many circRNAs increase with age in Caenorhabditis elegans, and that loss of circ-crh-1, an abundant age-accumulated circRNA, extends mean lifespan....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.