Article
circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan.
GeroScience - 1 Feb 2020
Haque Shahnaz, Ames Ryan M, Moore Karen, Pilling Luke C, Peters Luanne L, Bandinelli Stefania, Ferrucci Luigi, Harries Lorna W
Abstract excerpt
Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cellular senescence, their role in aging remains relatively unexplored. Here, we have assessed circRNA expression in aging human blood and followed up age-associated...
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