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Article

Reducing YAP expression in Pkd1 mutant mice does not improve the cystic phenotype.

Journal of cellular and molecular medicine - 1 Aug 2020

Formica Chiara, Kunnen Sandra, Dauwerse Johannes G, Mullick Adam E, Dijkstra Kyra L, Scharpfenecker Marion, Peters Dorien J M

Abstract excerpt

The Hippo pathway is a highly conserved signalling route involved in organ size regulation. The final effectors of this pathway are two transcriptional coactivators, yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (WWTR1 or TAZ). Previously, we showed aberrant activation of the Hippo pathway in autosomal-dominant polycystic kidney disease (ADPKD), suggesting that YAP/TAZ might...

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Share to Adaptor Proteins, Signal Transducing
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

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Share to Mice, Knockout

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Share to Protein Kinase C

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Source

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Identifiers

PMID: 32592332
DOI: 10.1111/jcmm.15512
PMCID: PMC7412403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Reducing YAP expression in Pkd1 mutant mice does not improve the cystic phenotype.PMID 32592332Read ↗

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