Article
Modulating F-actin organization induces organ growth by affecting the Hippo pathway.
The EMBO journal - 10 May 2011
Sansores-Garcia Leticia, Bossuyt Wouter, Wada Ken-Ichi, Yonemura Shigenobu, Tao Chunyao, Sasaki Hiroshi, Halder Georg
Abstract excerpt
The Hippo tumour suppressor pathway is a conserved signalling pathway that controls organ size. The core of the Hpo pathway is a kinase cascade, which in Drosophila involves the Hpo and Warts kinases that negatively regulate the activity of the transcriptional coactivator Yorkie. Although several additional components of the Hippo pathway have been discovered, the inputs that regulate Hippo signalling are not...
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