Article
Assessment of somatic mutations in urine and plasma of Wilms tumor patients.
Cancer medicine - 1 Aug 2020
Miguez Ana Carolina Kerekes, Barros Bruna D de Figueiredo, de Souza Jorge E S, da Costa Cecília Maria L, Cunha Isabela Werneck, Barbosa Paula Nicole Vieira P, Apezzato Maria Lúcia P, de Souza Sandro J, Carraro Dirce Maria
Abstract excerpt
Tumor DNA has been detected in body fluids of cancer patients. Somatic tumor mutations are being used as biomarkers in body fluids to monitor chemotherapy response as a minimally invasive tool. In this study, we evaluated the potential of tracking somatic mutations in free DNA of plasma and urine collected from Wilms tumor (WT) patients for monitoring treatment response. Wilms tumor is a pediatric renal tumor...
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