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Article

Predictors for progression in amyotrophic lateral sclerosis associated to SOD1 mutation: insight from two population-based registries.

Journal of neurology - 1 Dec 2023

Martinelli Ilaria, Ghezzi Andrea, Zucchi Elisabetta, Gianferrari Giulia, Ferri Laura, Moglia Cristina, Manera Umberto, Solero Luca, Vasta Rosario, Canosa Antonio, Grassano Maurizio, Brunetti Maura, Mazzini Letizia, De Marchi Fabiola, Simonini Cecilia, Fini Nicola, Vinceti Marco, Pinti Marcello, Chiò Adriano, Calvo Andrea, Mandrioli Jessica

Abstract excerpt

BACKGROUND: Uncovering distinct features and trajectories of amyotrophic lateral sclerosis (ALS) associated with SOD1 mutations (SOD1-ALS) can provide valuable insights for patient' counseling and stratification for trials, and interventions timing. Our study aims to pinpoint distinct clinical characteristics of SOD1-ALS by delving into genotype-phenotype correlations and factors that potentially impact disease...

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PMID: 37668704
DOI: 10.1007/s00415-023-11963-0

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