Article

Oncogenic CD44 is required for pancreatic cancer cell tumorigenesis and CD44 gene knockout is a new strategy for targeted pancreatic cancer therapy

2024-01-08

Abstract excerpt

<title>Abstract</title> <p>CD44 is a cancer stem cell marker and is aberrantly overexpressed in cancer stem/progenitor cells of malignant tumors. Overexpression of CD44 promotes carcinogenesis and is closely associated with poor prognosis in cancer patients, including pancreatic cancer. However, CD44-targeted drug against pancreatic cancer is unavailable in the clinical setting, and the effect of <italic>CD44</it...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db6fed8b-3f52-5827-bcb7-7d7057429463
DOI: 10.21203/rs.3.rs-3677039/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oncogenic CD44 is required for pancreatic cancer cell tumorigenesis and CD44 gene knockout is a new strategy for targeted pancreatic cancer therapyDOI 10.21203/rs.3.rs-3677039/v1Read

Inactivation of APC Induces CD34 Upregulation to Promote Epithelial-Mesenchymal Transition and Cancer Stem Cell Traits in Pancreatic Cancer.Semantic proximity Read

Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancerSemantic proximity Read

Identification of Pancreatic Cancer Stem CellsSemantic proximity Read

Differentially expressed miRNAs in cancer-stem-like cells: markers for tumor cell aggressiveness of pancreatic cancer.Semantic proximity Read

MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer.Semantic proximity Read

Transcriptomic and functional analysis of ANGPTL4 overexpression in pancreatic cancer nominates targets that reverse chemoresistanceSemantic proximity Read

DDX31: A Novel Functional Oncogene Promotes Migration and Proliferation of Pancreatic CancerSemantic proximity Read

Functional Characterization of miR-216a-5p and miR-125a-5p on Pancreatic Cancer Stem CellsSemantic proximity Read

Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic CancerSemantic proximity Read

Embryonic stem cell factors and pancreatic cancerSemantic proximity Read

Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cellsSemantic proximity Read

The Role of F11R in Pancreatic Cancer Malignancy and Its Clinical Implication as a Therapeutic TargetSemantic proximity Read