Article
An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant.
Chemical communications (Cambridge, England) - 21 Jul 2020
Correddu Danilo, Sharma Nabangshu, Kaur Simranjeet, Varnava Kyriakos G, Mbenza Naasson M, Sarojini Vijayalekshmi, Leung Ivanhoe K H
Abstract excerpt
An investigation using recombinant ribosomal proteins and synthetic peptide models was conducted to uncover the effect of the introduction of a negative charge at the C-terminal tail of ribosomal protein S15. Our results help provide a chemical rationale towards understanding how G2019S LRRK2, a common clinical mutation, causes Parkinson's disease.
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