Article
CTP synthase polymerization in germline cells of the developing Drosophila egg supports egg production.
Biology open - 21 Jul 2020
Simonet Jacqueline C, Foster Maya J, Lynch Eric M, Kollman Justin M, Nicholas Emmanuelle, O'Reilly Alana M, Peterson Jeffrey R
Abstract excerpt
Polymerization of metabolic enzymes into micron-scale assemblies is an emerging mechanism for regulating their activity. CTP synthase (CTPS) is an essential enzyme in the biosynthesis of the nucleotide CTP and undergoes regulated and reversible assembly into large filamentous structures in organisms from bacteria to humans. The purpose of these assemblies is unclear. A major challenge to addressing this question...
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