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Article

PRPS polymerization influences lens fiber organization in zebrafish.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2020

Begovich Kyle, Yelon Deborah, Wilhelm James E

Abstract excerpt

BACKGROUND: The self-assembly of metabolic enzymes into filaments or foci highlights an intriguing mechanism for the regulation of metabolic activity. Recently, we identified the conserved polymerization of phosphoribosyl pyrophosphate synthetase (PRPS), which catalyzes the first step in purine nucleotide synthesis, in yeast and cultured mammalian cells. While previous work has revealed that loss of PRPS activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32243675
DOI: 10.1002/dvdy.173
PMCID: PMC8370018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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