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Article

De novo evolved gene product NCYM in the pathogenesis and clinical outcome of human neuroblastomas and other cancers

4 Jun 2020

Abstract excerpt

NCYM is an antisense transcript of MYCN oncogene and promotes tumor progression. NCYM encodes a de novo protein whose open reading frame evolved from noncoding genomic regions in the ancestor of Homininae. Because of its topology, NCYM is always co-amplified with MYCN oncogene, and the mutual regulations between NCYM and MYCN maintain their expressions at high levels in MYCN-amplified tumors. NCYM stabilizes MYCN...

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PMID: 32577751
DOI: 10.1093/jjco/hyaa097

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