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Article

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Nature communications - 23 Jun 2020

Morris Elizabeth R, Caswell Sarah J, Kunzelmann Simone, Arnold Laurence H, Purkiss Andrew G, Kelly Geoff, Taylor Ian A

Abstract excerpt

SAMHD1 regulates cellular 2'-deoxynucleoside-5'-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2'-deoxynucleosides and triphosphate. In CD4+ myeloid lineage and resting T-cells, SAMHD1 blocks HIV-1 and other viral infections by depletion of the dNTP pool to a level that cannot support replication. SAMHD1 mutations are associated with the autoimmune disease Aicardi-Goutières syndrome...

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Identifiers

PMID: 32576829
DOI: 10.1038/s41467-020-16983-2
PMCID: PMC7311409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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