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Exploration of the effect of sequence variations located inside the binding pocket of HIV-1 and HIV-2 proteases

4 Apr 2018

Abstract excerpt

HIV-2 protease (PR2) is naturally resistant to most FDA (Food and Drug Administration)-approved HIV-1 protease inhibitors (PIs), a major antiretroviral class. In this study, we compared the PR1 and PR2 binding pockets extracted from structures complexed with 12 ligands. The comparison of PR1 and PR2 pocket properties showed that bound PR2 pockets were more hydrophobic with more oxygen atoms and fewer nitrogen...

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PMID: 29636521
DOI: 10.1038/s41598-018-24124-5

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