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Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells

23 Jun 2020

Abstract excerpt

It has been proposed that unmethylated insulin promoter fragments in plasma derive exclusively from β cells, reflect their recent demise, and can be used to assess β cell damage in type 1 diabetes. Herein we describe an ultrasensitive assay for detection of a β cell-specific DNA methylation signature, by simultaneous assessment of 6 DNA methylation markers, that identifies β cell DNA in mixtures containing as...

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PMID: 32573495
DOI: 10.1172/jci.insight.136579

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