Article
Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models.
Breast cancer research : BCR - 3 Aug 2021
Chew Nicole J, Lim Kam Sian Terry C C, Nguyen Elizabeth V, Shin Sung-Young, Yang Jessica, Hui Mun N, Deng Niantao, McLean Catriona A, Welm Alana L, Lim Elgene, Gregory Peter, Nottle Tim, Lang Tali, Vereker Melissa, Richardson Gary, Kerr Genevieve, Micati Diana, Jardé Thierry, Abud Helen E, Lee Rachel S, Swarbrick Alex, Daly Roger J
Abstract excerpt
BACKGROUND: Particular breast cancer subtypes pose a clinical challenge due to limited targeted therapeutic options and/or poor responses to the existing targeted therapies. While cell lines provide useful pre-clinical models, patient-derived xenografts (PDX) and organoids (PDO) provide significant advantages, including maintenance of genetic and phenotypic heterogeneity, 3D architecture and for PDX, tumor-stroma...
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