Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MESP2 variants contribute to conotruncal heart defects by inhibiting cardiac neural crest cell proliferation.

Journal of molecular medicine (Berlin, Germany) - 1 Jul 2020

Zhang Erge, Yang Jianping, Liu Yang, Hong Nanchao, Xie Huilin, Fu Qihua, Li Fen, Chen Sun, Yu Yu, Sun Kun

Abstract excerpt

Conotruncal heart defects (CTDs) are closely related to defective outflow tract (OFT) development, in which cardiac neural crest cells (CNCCs) play an indispensable role. However, the genetic etiology of CTDs remains unclear. Mesoderm posterior 2 (MESP2) is an important transcription factor regulating early cardiogenesis. Nevertheless, MESP2 variants have not been reported in congenital heart defect (CHD)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Heart Defects, Congenital

Share to Myocardium

Share to Neural Crest

Share to Organogenesis

Source

Identifiers

PMID: 32572506
DOI: 10.1007/s00109-020-01929-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MESP2 variants contribute to conotruncal heart defects by inhibiting cardiac neural crest cell proliferation.PMID 32572506Read ↗

Single-cell transcriptomic landscape of cardiac neural crest cell derivatives during embryonic and neonatal developmentSemantic proximity Read ↗

Identification of ZFPM2 mutations in sporadic conotruncal heart defect patients.Semantic proximity Read ↗

The Cardiac Neural Crest Cells in Heart Development and Congenital Heart DefectsSemantic proximity Read ↗

MESP1 Mutations in Patients with Congenital Heart Defects.Semantic proximity Read ↗

Identification of FOXH1 mutations in patients with sporadic conotruncal heart defect.Semantic proximity Read ↗

Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency.Semantic proximity Read ↗

Outflow Tract Formation—Embryonic Origins of Conotruncal Congenital Heart DiseaseSemantic proximity Read ↗

CHARGEd with neural crest defects.Semantic proximity Read ↗

Single cell transcriptomics uncovers a non-autonomous <i>Tbx1</i> -dependent genetic program controlling cardiac neural crest cell deployment and progressionSemantic proximity Read ↗

CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expressionSemantic proximity Read ↗

Mutations in fibroblast growth factor (FGF8) and FGF10 identified in patients with conotruncal defects.Semantic proximity Read ↗

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.