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Article

Mutations in fibroblast growth factor (FGF8) and FGF10 identified in patients with conotruncal defects.

Journal of translational medicine - 14 Jul 2020

Zhou Shuang, Wang Qingjie, Meng Zhuo, Peng Jiayu, Zhou Yue, Song Wenting, Wang Jian, Chen Sun, Sun Kun

Abstract excerpt

BACKGROUND: Conotruncal defects (CTDs) are a type of heterogeneous congenital heart diseases (CHDs), but little is known about their etiology. Increasing evidence has demonstrated that fibroblast growth factor (FGF) 8 and FGF10 may be involved in the pathogenesis of CTDs. METHODS: The variants of FGF8 and FGF10 in unrelated Chinese Han patients with CHDs (n = 585), and healthy controls (n = 319) were...

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Identifiers

PMID: 32664970
DOI: 10.1186/s12967-020-02445-2
PMCID: PMC7362408

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