Article
Genetic underpinnings in Alzheimer's disease - a review.
Reviews in the neurosciences - 26 Jan 2018
Moustafa Ahmed A, Hassan Mubashir, Hewedi Doaa H, Hewedi Iman, Garami Julia K, Al Ashwal Hany, Zaki Nazar, Seo Sung-Yum, Cutsuridis Vassilis, Angulo Sergio L, Natesh Joman Y, Herzallah Mohammad M, Frydecka Dorota, Misiak Błażej, Salama Mohamed, Mohamed Wael, El Haj Mohamad, Hornberger Michael
Abstract excerpt
In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree...
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