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Article

Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways.

Kidney international - 1 Feb 2018

Chen Neal X, O'Neill Kalisha D, Moe Sharon M

Abstract excerpt

In patients with chronic kidney and end-stage renal diseases, the major risk factor for progression of arterial calcification is the presence of existing (baseline) calcification. Here, we tested whether calcification of arteries is extended from calcified vascular smooth muscle cells (VSMCs) to adjacent normal cells by matrix vesicle-induced alteration of cell signaling. Matrix vesicles isolated from VSMC of...

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Identifiers

PMID: 29032812
DOI: 10.1016/j.kint.2017.07.019
PMCID: PMC8211355

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NOX1

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