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Article

The Urokinase Receptor in the Central Nervous System

1 Mar 2011

Abstract excerpt

The urokinase receptor (uPAR) is a multifunctional glycosylphosphatidylinositol-anchored protein that regulates important processes such as gene expression, cell proliferation, adhesion, migration, invasion, and metastasis. uPAR is an essential component of the plasminogen activation cascade, a protease receptor that binds the urokinase-type plasminogen activator. uPAR is also an adhesion-modulating receptor, and...

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PMID: 20874700
DOI: 10.2174/187152711794480393

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