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Article

Donating Otx2 to support neighboring neuron survival.

BMB reports - 1 Feb 2016

Kim Hyoung-Tai, Prochiantz Alain, Kim Jin Woo

Abstract excerpt

Mutations of orthodentricle homeobox 2 (OTX2) in human and mice often cause retinal dystrophy and nyctalopia, suggesting a role of OTX2 in mature retina, in addition to its functions in the development of the eye and retina. In support of this, the number of bipolar cells in Otx2＋/- post-natal mouse retina was found to be significantly lower than normal. Degeneration of the cells becomes greater as the mice age,...

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Source

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Identifiers

PMID: 26779998
DOI: 10.5483/bmbrep.2016.49.2.006
PMCID: PMC4915118

Genes

OTX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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