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Article

SP1‐mediated upregulation of LINGO‐1 promotes degeneration of retinal ganglion cells in optic nerve injury

19 Jun 2020

Abstract excerpt

BACKGROUNDS: Insults to the axons in the optic nerve head are the primary cause of loss of retinal ganglion cells (RGCs) in traumatic, ischemic nerve injury or degenerative ocular diseases. The central nervous system-specific leucine-rich repeat protein, LINGO-1, negatively regulates axon regeneration and neuronal survival after injury. However, the upstream molecular mechanisms that regulate LINGO-1 signaling...

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Share to Axon Guidance and Neuronal Signaling
Share to Glaucoma and retinal disorders
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PMID: 32562344
DOI: 10.1111/cns.13426

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