Article
The heterotrimeric G-protein beta subunit Gpb1 controls hyphal growth under low oxygen conditions through the protein kinase A pathway and is essential for virulence in the fungus Mucor circinelloides.
Cellular microbiology - 1 Oct 2020
Valle-Maldonado Marco Iván, Patiño-Medina José Alberto, Pérez-Arques Carlos, Reyes-Mares Nancy Yadira, Jácome-Galarza Irvin Eduardo, Ortíz-Alvarado Rafael, Vellanki Sandeep, Ramírez-Díaz Martha Isela, Lee Soo Chan, Garre Victoriano, Meza-Carmen Víctor
Abstract excerpt
Mucor circinelloides, a dimorphic opportunistic pathogen, expresses three heterotrimeric G-protein beta subunits (Gpb1, Gpb2 and Gpb3). The Gpb1-encoding gene is up-regulated during mycelial growth compared with that in the spore or yeast stage. gpb1 deletion mutation analysis revealed its relevance for an adequate development during the dimorphic transition and for hyphal growth under low oxygen concentrations....
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