Article
The G-protein alpha-subunit GasC plays a major role in germination in the dimorphic fungus Penicillium marneffei.
Genetics - 1 Jun 2003
Zuber Sophie, Hynes Michael J, Andrianopoulos Alex
Abstract excerpt
The opportunistic human pathogen Penicillium marneffei exhibits a temperature-dependent dimorphic switch. At 25 degrees, multinucleate, septate hyphae that can undergo differentiation to produce asexual spores (conidia) are produced. At 37 degrees hyphae undergo arthroconidiation to produce uninucleate yeast cells that divide by fission. This work describes the cloning of the P. marneffei gasC gene encoding a...
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