Article
G(alpha) and Gbeta proteins regulate the cyclic AMP pathway that is required for development and pathogenicity of the phytopathogen Mycosphaerella graminicola.
Eukaryotic cell - 1 Jul 2009
Mehrabi Rahim, Ben M'Barek Sarrah, van der Lee Theo A J, Waalwijk Cees, de Wit Pierre J G M, Kema Gerrit H J
Abstract excerpt
We identified and functionally characterized genes encoding three Galpha proteins and one Gbeta protein in the dimorphic fungal wheat pathogen Mycosphaerella graminicola, which we designated MgGpa1, MgGpa2, MgGpa3, and MgGpb1, respectively. Sequence comparisons and phylogenetic analyses showed that MgGPA1 and MgGPA3 are most related to the mammalian Galpha(i) and Galpha(s) families, respectively, whereas MgGPA2...
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