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The G-Protein β Subunit GPB1 Is Required for Mating and Haploid Fruiting in <i>Cryptococcus neoformans</i>

1 Jan 2000

Abstract excerpt

Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle. The gene encoding a heterotrimeric G-protein beta subunit, GPB1, was cloned and disrupted. gpb1 mutant strains are sterile, indicating a role for this gene in mating. GPB1 plays an active role in mediating responses to pheromones in early mating steps (conjugation tube formation and cell fusion) and signals via a...

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PMID: 10594037
DOI: 10.1128/mcb.20.1.352-362.2000

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The G-Protein β Subunit GPB1 Is Required for Mating and Haploid Fruiting in <i>Cryptococcus neoformans</i>PMID 10594037Read ↗

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