Article
A subunit of protein kinase a regulates growth and differentiation in the fungus Mucor circinelloides.
Eukaryotic cell - 1 Jul 2009
Ocampo J, Fernandez Nuñez L, Silva F, Pereyra E, Moreno S, Garre V, Rossi S
Abstract excerpt
The cyclic AMP (cAMP)-dependent protein kinase A (PKA) signaling pathway plays a role in regulating development, growth, and virulence in a number of fungi. To determine whether PKA plays a similar function in zygomycete fungi, a mutant of Mucor circinelloides was generated that lacks pkaR1, one of the regulatory subunits of PKA. The mutant showed a reduction in growth and alterations in germination rates, cell...
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