Article
Genetic aberrations and survival in plasma cell leukemia.
Leukemia - 1 May 2008
Tiedemann R E, Gonzalez-Paz N, Kyle R A, Santana-Davila R, Price-Troska T, Van Wier S A, Chng W J, Ketterling R P, Gertz M A, Henderson K, Greipp P R, Dispenzieri A, Lacy M Q, Rajkumar S V, Bergsagel P L, Stewart A K, Fonseca R
Abstract excerpt
Plasma cell leukemia (PCL) is an aggressive and rare hematological malignancy that originates either as primary disease (pPCL) or as a secondary leukemic transformation (sPCL) of multiple myeloma (MM). We report here the genetic aberrations and survival of 80 patients with pPCL or sPCL and make comparisons with 439 cases of MM. pPCL presents a decade earlier than sPCL (54.7 vs 65.3 years) and is associated with...
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