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Article

1q amplification and PHF19 expressing high-risk cells are associated with relapsed/refractory multiple myeloma.

Nature communications - 16 May 2024

Johnson Travis S, Sudha Parvathi, Liu Enze, Becker Nathan, Robertson Sylvia, Blaney Patrick, Morgan Gareth, Chopra Vivek S, Dos Santos Cedric, Nixon Michael, Huang Kun, Suvannasankha Attaya, Zaid Mohammad Abu, Abonour Rafat, Walker Brian A

Abstract excerpt

Multiple Myeloma is an incurable plasma cell malignancy with a poor survival rate that is usually treated with immunomodulatory drugs (iMiDs) and proteosome inhibitors (PIs). The malignant plasma cells quickly become resistant to these agents causing relapse and uncontrolled growth of resistant clones. From whole genome sequencing (WGS) and RNA sequencing (RNA-seq) studies, different high-risk translocation, copy...

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Topics

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Share to Chromosomes, Human, Pair 1
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Gene Expression Regulation, Neoplastic

Share to Multiple Myeloma

Share to Neoplasm Recurrence, Local

Share to Plasma Cells

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 38755140
DOI: 10.1038/s41467-024-48327-9
PMCID: PMC11099140

Genes

PHF19
PBX1
TF
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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1q amplification and PHF19 expressing high-risk cells are associated with relapsed/refractory multiple myeloma.PMID 38755140Read ↗

Identifying 1q amplification and PHF19 expressing high-risk cells associated with relapsed/refractory multiple myelomaSemantic proximity Read ↗

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Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypesSemantic proximity Read ↗

Single Cell Characterization of Myeloma and its Precursor Conditions Reveals Transcriptional Signatures of Early TumorigenesisSemantic proximity Read ↗

Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive diseaseSemantic proximity Read ↗

Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesisSemantic proximity Read ↗

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