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Article

A multicenter study investigating the genetic analysis of childhood steroid-resistant nephrotic syndrome: Variants in COL4A5 may not be coincidental.

PloS one - 1 Jan 2024

Li Sheng, Hu Miaoyue, He Chao, Sun Yu, Huang Weifang, Lei Fengying, Liu Yunguang, Huang Zengpo, Meng Yongqiu, Liu Wenjing, Lei Xianqiang, Dong Yanfang, Lin Zihui, Huang Chunlin, Zhao Rihong, Qin Yuanhan

Abstract excerpt

This study aimed to discuss the pathogenic hereditary factors of children with steroid-resistant nephrotic syndrome (SRNS) in Guangxi, China. We recruited 89 patients with SRNS or infantile NS from five major pediatric nephrology centers in Guangxi, and conducted a retrospective analysis of clinical data. Whole-exome sequencing analysis was also performed on all patients. The risk of progression to chronic kidney...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39625990
DOI: 10.1371/journal.pone.0304864
PMCID: PMC11614205

Genes

COL4A5
NPHS1
COL4A6
LMX1B
NPHS2
PAX2
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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